<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-4204 4204-30723 Germany 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA
2 NRTI+NNRTI+RTV+TPV 18

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, L74V, M184V, L210W, T215Y K219R K101E, G190S   T39TA, K43E, E44A, V118I, K122E, D123E, I142V, D177E, V189VI, G196E, T200A, E203D, H208Y, R211K, D237E, A272P, T286A, E297K, D324DE, E344D, M357T, A371V, K390R  
>4204-30723| codons 1-398
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICAELEEAGKISKIGPENPYNTPV
FAIKKKNSTKWRKVVDFRELNKRTQDFWEVQLGIPHPAGLEKKKSVTVLDVGDAYFSIPL
DEEFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPEIVI
YQYVDDLYISSDLEIEQHRAKIDELRQYLWKWGFYTPDRKHQKEPPFLWMGYELHPEKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGAKALTEVIPLTKEAE
LELAENREILKEPVHGVYYDPSKELIAEIQKQGQGQWTYQIYQDPFKNLKTGKYARTRGA
HTNDVKQLTEVVQKIATESIVIWGKTPKFRLPIQKETW

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I, I47V, I54V, I84V, L90M G73S, L89V L10I, K14R, K20I, R57K, L63P, A71IV, I72L, I85IV, I93L  
>4204-30723| codons 1-99
PQITLWQRPIVTIRIGGQLIEALLDTGADDTVLEEMNLPGRWKPKIVGGIGGFVKVKQYD
QIPIEICGHKVLSTVLVGPTPVNVVGRNVMTQLGCTLNF

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006