Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-4204 | 4204-30723 | Germany | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
| 2 | NRTI+NNRTI+RTV+TPV | 18 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L74V, M184V, L210W, T215Y | K219R | K101E, G190S | T39TA, K43E, E44A, V118I, K122E, D123E, I142V, D177E, V189VI, G196E, T200A, E203D, H208Y, R211K, D237E, A272P, T286A, E297K, D324DE, E344D, M357T, A371V, K390R |
| >4204-30723| codons 1-398 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICAELEEAGKISKIGPENPYNTPV FAIKKKNSTKWRKVVDFRELNKRTQDFWEVQLGIPHPAGLEKKKSVTVLDVGDAYFSIPL DEEFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPEIVI YQYVDDLYISSDLEIEQHRAKIDELRQYLWKWGFYTPDRKHQKEPPFLWMGYELHPEKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGAKALTEVIPLTKEAE LELAENREILKEPVHGVYYDPSKELIAEIQKQGQGQWTYQIYQDPFKNLKTGKYARTRGA HTNDVKQLTEVVQKIATESIVIWGKTPKFRLPIQKETW |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I47V, I54V, I84V, L90M | G73S, L89V | L10I, K14R, K20I, R57K, L63P, A71IV, I72L, I85IV, I93L |
| >4204-30723| codons 1-99 PQITLWQRPIVTIRIGGQLIEALLDTGADDTVLEEMNLPGRWKPKIVGGIGGFVKVKQYD QIPIEICGHKVLSTVLVGPTPVNVVGRNVMTQLGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |