<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-4202 4202-30804 Germany 2003 HIV1 A Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
    L10V, I13V, K14KR, I15V, G16E, E35D, M36I, R41K, K45R, L63T, H69K  
>4202-30804| codons 1-99
PQITLWQRPVVTVRVEGQLKEALLDTGADDTVLEDINLPGKWKPRMIGGIGGFIKVRQYD
QITIEICGKKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
    K103KN   V35T, T39N, T69S, K122E, D123DN, I135T, S162C, K173S, Q174K, D177E, G196E, T200A, Q207A, R211S, V245K, E248D, D250E, S251C, K275KR, T286A, E291D, I293V, P294T, L295M, E312D, G335D, I341IV, R356K, M357K, G359S, T369A, I375V, A376S, T377L, T386I, K390R, E399ED  
>4202-30804| codons 1-399
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTEICNEMEKEGKISKIGPENPYNTPV
FAIKKKDSSKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL
DENFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQCSMTKILEPFRSKNPEIVI
YQYMDDLYVGSDLEIEQHRAKIEELRAHLLSWGFTTPDKKHQKEPPFLWMGYELHPDKWT
VQPIKLPDKECWTVNDIQKLVGKLNWASQIYAGIRVKQLCKLLRGAKALTDVVTMTEEAE
LELAENREILKDPVHGVYYDPSKDLIAEIQKQGQDQWTYQVYQEPFKNLKTGKYAKKRSA
HTNDVKQLAEAVQKVSLESIVIWGKIPKFRLPIQKETWD

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006