Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-4202 | 4202-30804 | Germany | 2003 | HIV1 | A | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| L10V, I13V, K14KR, I15V, G16E, E35D, M36I, R41K, K45R, L63T, H69K |
| >4202-30804| codons 1-99 PQITLWQRPVVTVRVEGQLKEALLDTGADDTVLEDINLPGKWKPRMIGGIGGFIKVRQYD QITIEICGKKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| K103KN | V35T, T39N, T69S, K122E, D123DN, I135T, S162C, K173S, Q174K, D177E, G196E, T200A, Q207A, R211S, V245K, E248D, D250E, S251C, K275KR, T286A, E291D, I293V, P294T, L295M, E312D, G335D, I341IV, R356K, M357K, G359S, T369A, I375V, A376S, T377L, T386I, K390R, E399ED |
| >4202-30804| codons 1-399 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTEICNEMEKEGKISKIGPENPYNTPV FAIKKKDSSKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL DENFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQCSMTKILEPFRSKNPEIVI YQYMDDLYVGSDLEIEQHRAKIEELRAHLLSWGFTTPDKKHQKEPPFLWMGYELHPDKWT VQPIKLPDKECWTVNDIQKLVGKLNWASQIYAGIRVKQLCKLLRGAKALTDVVTMTEEAE LELAENREILKDPVHGVYYDPSKDLIAEIQKQGQDQWTYQVYQEPFKNLKTGKYAKKRSA HTNDVKQLAEAVQKVSLESIVIWGKIPKFRLPIQKETWD |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |