Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-4201 | 4201-30724 | Germany | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, V82A, I84V, L90M | N83D | L10I, T12P, K14R, K20R, E34R, M36I, N37S, R41K, I62V, L63P, H69HY, A71AT, I72EV, I93L |
| >4201-30724| codons 1-99 PQITLWQRPIVPIRIGGQLREALLDTGADDTVLREISLPGKWKPKIIGGIGGFVKVRQYD QVPIEICGYKTVGTVLVGPTPADVIGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, M184V, L210W, T215Y | K219N | K103N | K20KR, K32KQ, V60VI, V118I, K122E, D123N, I135T, E138EQ, T200TA, R211K, D218DE, V245T, I293V, K311KR, I326V, Q334L, A355AS, G359S, A371AT, S379C, E396EG |
| >4201-30724| codons 1-399 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIQALVEICTELEKEGKISKIGPENPYNTPI FAIKKKNSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSIPL DENFRKYTAFTIPSTNNQTPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYVDDLYVGSDLEIGQHRAKIEELRQHLWKWGFYTPENKHQKEPPFLWMGYELHPDKWT VQPITLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGTKALTEVVPLTEEAE LELAENREILREPVHGVYYDPSKDLVAEIQKQGLGQWTYQIYQEPFKNLKTGKYSRMRSA HTNDVKQLTETVQKIATECIVIWGKTPKFKLPIQKGTWE |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |