<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-4201 4201-30724 Germany 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I, I54V, V82A, I84V, L90M N83D L10I, T12P, K14R, K20R, E34R, M36I, N37S, R41K, I62V, L63P, H69HY, A71AT, I72EV, I93L  
>4201-30724| codons 1-99
PQITLWQRPIVPIRIGGQLREALLDTGADDTVLREISLPGKWKPKIIGGIGGFVKVRQYD
QVPIEICGYKTVGTVLVGPTPADVIGRNLMTQLGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, M184V, L210W, T215Y K219N K103N   K20KR, K32KQ, V60VI, V118I, K122E, D123N, I135T, E138EQ, T200TA, R211K, D218DE, V245T, I293V, K311KR, I326V, Q334L, A355AS, G359S, A371AT, S379C, E396EG  
>4201-30724| codons 1-399
PISPIETVPVKLKPGMDGPRVKQWPLTEEKIQALVEICTELEKEGKISKIGPENPYNTPI
FAIKKKNSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSIPL
DENFRKYTAFTIPSTNNQTPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI
YQYVDDLYVGSDLEIGQHRAKIEELRQHLWKWGFYTPENKHQKEPPFLWMGYELHPDKWT
VQPITLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGTKALTEVVPLTEEAE
LELAENREILREPVHGVYYDPSKDLVAEIQKQGLGQWTYQIYQEPFKNLKTGKYSRMRSA
HTNDVKQLTETVQKIATECIVIWGKTPKFKLPIQKGTWE

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006