Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA1455 | CA7737 | U.S. | 1998 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | DDI+ AZT | 183 |
| 2 | D4T | 56 |
| 3 | SQV+ D4T | 21 |
| 4 | DDC+NFV+NVP | 90 |
| 5 | SQV+ RTV+ EFV+ ABC | 27 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I84V, L90M | G73S | L10I, I15V, L19P, K20I, E35D, M36I, R41K, I62V, L63P, A71V |
| >CA7737| codons 1-99 PQITLWQRPIVTIKVGGQPIEALLDTGADDTVLEDINLPGKWKPKMIGGIGGFIKVRQYD QVPIEICGHKVISTVLVGPTPVNVIGRNLMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, K70R, L74V, T215Y | D67G, K219E | K101E, Y181V, G190A | E28A, V60I, S68G, K122E, I135T, I178M |
| >CA7736| codons 1-272 PISPIETVPVKLKPGMDGPKVKQWPLTAEKIKALVEICTELEKEGKISKIGPENPYNTPI FAIKKKGGTRWRKVVDFRELNKRTQDFWEVQLGIPHPAGLEKKKSVTVLDVGDAYFSVPL DEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDMVI VQYMDDLYVASDLEIGQHRTKIEELRQHLLRWGFYTPDEKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYA |
References
| Author | Title | Citation |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |
| Rhee, SY | Predictive Value of HIV-1 Genotypic Resistance Test Interpretation Algorithms. | J Infect Dis, 2009 |