Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-4200 | 4200-30515 | Germany | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, T69D, L74I, V75M, M184V, L210W, T215F | K219W | Y181C, G190S | A98G | T7P, V35I, T39E, K64H, V118I, K122E, I135T, S162C, G196E, E203K, E204EG, Q207E, H208Y, K223Q, L228R, I293V, K311R, D324E, A355G, R356K, G359S |
| >4200-30515| codons 1-400 PISPIEPVPVKLKPGMDGPKVKQWPLTEEKIKALIEICEELEKEGKISKIGPENPYNTPV FAIHKKDSDKWRKIMDFRELNKRTQDFWEVQLGIPHPGGLKKKKSVTVLDVGDAYFSIPL DEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQCSMTKILEPFRKQNPDIVI CQYVDDLYVSSDLEIEQHRTKIKGLREYLWRWGFFTPDWKHQQEPPFRWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGTKALTEVVPLTEEAE LELAENREILREPVHGVYYDPSKELIAEIQKQGQGQWTYQIYQEPFKNLKTGKYGKMRSA HTNDVKQLTEAVQKIATESIVIWGKTPKFKLPIQKETWEA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, I54L, V82A, L90M | L10F, L33F, K43T, F53L, G73A | G16A, L19I, L24F, E34Q, K55R, D60E, I62V, L63P, I64M, A71I, I72L, I93L |
| >4200-30515| codons 1-99 PQITLWQRPFVTIKIAGQIKEALFDTGADDTVFQEMNLPGRWTPKLIGGIGGLLRVRQYE QVPMEICGHKILATVLVGPTPANIIGRNLMTQLGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |