<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-4200 4200-30515 Germany 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46L, I54L, V82A, L90M L10F, L33F, K43T, F53L, G73A G16A, L19I, L24F, E34Q, K55R, D60E, I62V, L63P, I64M, A71I, I72L, I93L  
>4200-30515| codons 1-99
PQITLWQRPFVTIKIAGQIKEALFDTGADDTVFQEMNLPGRWTPKLIGGIGGLLRVRQYE
QVPMEICGHKILATVLVGPTPANIIGRNLMTQLGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, T69D, L74I, V75M, M184V, L210W, T215F K219W Y181C, G190S A98G T7P, V35I, T39E, K64H, V118I, K122E, I135T, S162C, G196E, E203K, E204EG, Q207E, H208Y, K223Q, L228R, I293V, K311R, D324E, A355G, R356K, G359S  
>4200-30515| codons 1-400
PISPIEPVPVKLKPGMDGPKVKQWPLTEEKIKALIEICEELEKEGKISKIGPENPYNTPV
FAIHKKDSDKWRKIMDFRELNKRTQDFWEVQLGIPHPGGLKKKKSVTVLDVGDAYFSIPL
DEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQCSMTKILEPFRKQNPDIVI
CQYVDDLYVSSDLEIEQHRTKIKGLREYLWRWGFFTPDWKHQQEPPFRWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGTKALTEVVPLTEEAE
LELAENREILREPVHGVYYDPSKELIAEIQKQGQGQWTYQIYQEPFKNLKTGKYGKMRSA
HTNDVKQLTEAVQKIATESIVIWGKTPKFKLPIQKETWEA

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006