Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-4199 | 4199-30507 | Germany | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69DGNS, L74LI, L210W, T215Y | K219E | K101KE, Y181YC, G190S | K20R, T39TA, E44D, V60I, V106VI, K122E, Q174N, I178M, V189VI, G196E, Q197K, T200A, R211RK, Q278H, R284RK, T286A, I293V, P294S, E297KR, M357V, A360AV, A376S, T386V, K390R |
| >4199-30507| codons 2-399 ISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALVEICAELEKDGKISKIGPENPYNTPIF AIKKKNSSKWRKIVDFRELNKRTQDFWEVQLGIPHPAGLEKKKSITVLDVGDAYFSVPLD EDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKNNPDMVIC QYMDDLYISSDLEIEKHRAKIEELRQHLWKWGFYTPDEKHQKEPPFLWMGYELHPDKWTV QPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKHLCKLLKGAKALTEVVSLTREAEL ELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARVRGVH TNDVKQLTEAVQKISTESIVIWGKVPKFRLPIQKETWE |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32I, I47V, G48M, I54M, V82A, L90M | L33F, M46V | L10V, I13IV, K14T, L19Q, K20R, E35D, M36I, N37D, I62V, L63PS, I64IM, K70KE, A71V, T74E, V77VI, L89IM, I93L |
| >4199-30507| codons 1-99 PQITLWQRPVVTVTIGGQQREALLDTGADDTIFEDIDLPGRWKPKVVMGIGGFMKVRQYD QVSMEICGHEVIGEVLIGPTPANIIGRNMMTQLGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |