<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-4199 4199-30507 Germany 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
V32I, I47V, G48M, I54M, V82A, L90M L33F, M46V L10V, I13IV, K14T, L19Q, K20R, E35D, M36I, N37D, I62V, L63PS, I64IM, K70KE, A71V, T74E, V77VI, L89IM, I93L  
>4199-30507| codons 1-99
PQITLWQRPVVTVTIGGQQREALLDTGADDTIFEDIDLPGRWKPKVVMGIGGFMKVRQYD
QVSMEICGHEVIGEVLIGPTPANIIGRNMMTQLGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, T69DGNS, L74LI, L210W, T215Y K219E K101KE, Y181YC, G190S   K20R, T39TA, E44D, V60I, V106VI, K122E, Q174N, I178M, V189VI, G196E, Q197K, T200A, R211RK, Q278H, R284RK, T286A, I293V, P294S, E297KR, M357V, A360AV, A376S, T386V, K390R  
>4199-30507| codons 2-399
ISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALVEICAELEKDGKISKIGPENPYNTPIF
AIKKKNSSKWRKIVDFRELNKRTQDFWEVQLGIPHPAGLEKKKSITVLDVGDAYFSVPLD
EDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKNNPDMVIC
QYMDDLYISSDLEIEKHRAKIEELRQHLWKWGFYTPDEKHQKEPPFLWMGYELHPDKWTV
QPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKHLCKLLKGAKALTEVVSLTREAEL
ELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARVRGVH
TNDVKQLTEAVQKISTESIVIWGKVPKFRLPIQKETWE

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006