Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-4196 | 4196-30519 | Germany | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, K70R, L74I, L210W, T215Y | K219E | K103N, Y181YC | V108I | K20R, V35M, T39A, E40D, S68G, D123E, I135L, S162D, I178L, I202V, D218E, L228H, A272P, I326IT, Q334H, T338S, K350R, A360V, Q367L, S379C |
| >4196-30519| codons 1-400 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALMEICADLEKEGKISKIGPENPYNTPV FAIKKKNGTRWRKIVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTILDVGDAYFSVPL DKEFRKYTAFTIPSLNNETPGIRYQYNVLPQGWKGSPAIFQDSMTKILEPFRKQNPDLVI CQYMDDLYVGSDLEIGQHRTKVEELRQHLWRWGFYTPEEKHQKEPPFHWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKALTEVIPLTEEAE LELAENREILKEPVHGVYYDPSKDLTAEIQKQGHGQWSYQIYQEPFKNLRTGKYARMRGV HTNDVKLLTEAVQKIATECIVIWGKTPKFKLPIQKETWEA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, I54V, V82A, L90M | L23I, K43T, F53FL, Q58E | L10I, L63P, A71V, I93IL |
| >4196-30519| codons 1-99 PQITLWQRPIVTIKIGGQLKEAILDTGADDTVLEEMNLPGRWTPKLIGGIGGLVKVREYD QIPIEICGHKVIGTVLVGPTPANIIGRNLMTQLGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |