<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-4196 4196-30519 Germany 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, K70R, L74I, L210W, T215Y K219E K103N, Y181YC V108I K20R, V35M, T39A, E40D, S68G, D123E, I135L, S162D, I178L, I202V, D218E, L228H, A272P, I326IT, Q334H, T338S, K350R, A360V, Q367L, S379C  
>4196-30519| codons 1-400
PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALMEICADLEKEGKISKIGPENPYNTPV
FAIKKKNGTRWRKIVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTILDVGDAYFSVPL
DKEFRKYTAFTIPSLNNETPGIRYQYNVLPQGWKGSPAIFQDSMTKILEPFRKQNPDLVI
CQYMDDLYVGSDLEIGQHRTKVEELRQHLWRWGFYTPEEKHQKEPPFHWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKALTEVIPLTEEAE
LELAENREILKEPVHGVYYDPSKDLTAEIQKQGHGQWSYQIYQEPFKNLRTGKYARMRGV
HTNDVKLLTEAVQKIATECIVIWGKTPKFKLPIQKETWEA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46L, I54V, V82A, L90M L23I, K43T, F53FL, Q58E L10I, L63P, A71V, I93IL  
>4196-30519| codons 1-99
PQITLWQRPIVTIKIGGQLKEAILDTGADDTVLEEMNLPGRWTPKLIGGIGGLVKVREYD
QIPIEICGHKVIGTVLVGPTPANIIGRNLMTQLGCTLNF

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006