Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-4195 | 4195-30508 | Germany | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, K70R, M184I, L210W, T215Y | K219E | Y181C, G190A | A98G | K20R, T39E, E44D, K102Q, V118I, S162C, V179I, E203D, H208Y, R211K, K223E, L228H, V245Q, K277R, A288S, E297K, I329L, Q334E, M357T, R358K, G359S, S379C |
| >4195-30508| codons 1-399 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALVEICEELEKDGKISKIGPENPYNTPV FAIKKKNSTRWRKLVDFRELNKRTQDFWEVQLGIPHPGGLKQKKSVTVLDVGDAYFSIPL DKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQCSMTKILEPFRKQNPDIII CQYIDDLYVASDLEIGQHRTKIDELRQYLWKWGFYTPDEKHQEEPPFHWMGYELHPDKWT VQPIQLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVRQLCKLLRGTKSLTEVIPLTKEAE LELAENREILKEPVHGVYYDPSKDLIAELQKQGEGQWTYQIYQEPFKNLKTGKYARTKSA HTNDVKQLTEAVQKIATECIVIWGKTPKFKLPIQKETWE |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I54V, L90M | L10I, I15V, E35D, M36I, N37S, R57K, L63P, A71V, V77I, I93L |
| >4195-30508| codons 1-99 PQITLWQRPIVTIKVGGQLKEALLDTGADDTVLEDISLPGRWKPKMIGGIGGFVKVKQYD QIPIEICGHKVIGTVLIGPTPVNIIGRNLMTQLGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |