<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-4195 4195-30508 Germany 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, K70R, M184I, L210W, T215Y K219E Y181C, G190A A98G K20R, T39E, E44D, K102Q, V118I, S162C, V179I, E203D, H208Y, R211K, K223E, L228H, V245Q, K277R, A288S, E297K, I329L, Q334E, M357T, R358K, G359S, S379C  
>4195-30508| codons 1-399
PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALVEICEELEKDGKISKIGPENPYNTPV
FAIKKKNSTRWRKLVDFRELNKRTQDFWEVQLGIPHPGGLKQKKSVTVLDVGDAYFSIPL
DKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQCSMTKILEPFRKQNPDIII
CQYIDDLYVASDLEIGQHRTKIDELRQYLWKWGFYTPDEKHQEEPPFHWMGYELHPDKWT
VQPIQLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVRQLCKLLRGTKSLTEVIPLTKEAE
LELAENREILKEPVHGVYYDPSKDLIAELQKQGEGQWTYQIYQEPFKNLKTGKYARTKSA
HTNDVKQLTEAVQKIATECIVIWGKTPKFKLPIQKETWE

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
I54V, L90M   L10I, I15V, E35D, M36I, N37S, R57K, L63P, A71V, V77I, I93L  
>4195-30508| codons 1-99
PQITLWQRPIVTIKVGGQLKEALLDTGADDTVLEDISLPGRWKPKMIGGIGGFVKVKQYD
QIPIEICGHKVIGTVLIGPTPVNIIGRNLMTQLGCTLNF

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006