Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-4192 | 4192-30508 | Germany | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| G48V, I50IV, I54AV, V82A, L90M | L33F, G73GS | I3IF, L10I, I62V, L63P, A71V, V77I, I93L |
| >4192-30508| codons 1-99 PQFTLWQRPIVTIKIGGQLKEALLDTGADDTVFEEMNLPGRWKPKMIVGVGGFVKVRQYD QVPIEICGHKVISTVLIGPTPANIIGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, M184V, T215Y | K103N | P4PS, K20R, K122E, D123N, I178L, V189VI, T200A, E203D, Q207E, A272P, T286A, S322SA, Q334V, T338TS, R356K, M357K, K390R, Q394L |
| >4192-30508| codons 1-399 PISSIETVPVKLKPGMDGPRVKQWPLTEEKIKALVEICTELEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL DENFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDLVI YQYVDDLYIGSDLEIGQHRAKIDELREHLLRWGFYTPDKKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGAKALTEVIPLTEEAE LELAENREILKEPVHGVYYDPAKDLIAEIQKQGVGQWSYQIYQEPFKNLKTGKYAKKRGA HTNDVKQLTEAVQKIATESIVIWGKTPKFRLPILKETWE |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |