Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-4191 | 4191-30430 | Germany | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54L, I84V, L90M | V11I, L33LF, G73S, L89MV | L10I, I15V, K20I, N37S, I62V, L63P, A71T, I72L, V77VI, I85V |
| >4191-30430| codons 1-99 PQITLWQRPIITIKVGGQLIEALLDTGADDTVFEEMSLPGRWKPKIIGGIGGFLKVRQYD QVPIEICGHKTLSTVLIGPTPVNVVGRNVMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, K70G, M184V, L210W, T215Y | D67G | V179D, Y318YF | S68G, K102Q, K103R, K104KR, K122E, I135T, E138A, I202V, A272P, K281KR, A288S, V292I, I293V, S322T, P345Q, A376S, T386I, K390R |
| >4191-30430| codons 1-399 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEKEGKISKIGPENPYNTPV FAIKKKGGTGWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKQRRSVTVLDVGDAYFSVPL DEDFRKYTAFTIPSTNNATPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIDI YQYVDDLYVGSDLEIGQHRTKVEELRQHLWRWGFYTPDKKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCRLLRGTKSLTEIVPLTEEAE LELAENREILKEPVHGVFYDPTKDLIAEIQKQGQGQWTYQIYQEQFKNLKTGKYARMRGA HTNDVKQLTEAVQKISTESIVIWGKIPKFRLPIQKETWE |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |