<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-4191 4191-30430 Germany 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I, I54L, I84V, L90M V11I, L33LF, G73S, L89MV L10I, I15V, K20I, N37S, I62V, L63P, A71T, I72L, V77VI, I85V  
>4191-30430| codons 1-99
PQITLWQRPIITIKVGGQLIEALLDTGADDTVFEEMSLPGRWKPKIIGGIGGFLKVRQYD
QVPIEICGHKTLSTVLIGPTPVNVVGRNVMTQIGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, K70G, M184V, L210W, T215Y D67G   V179D, Y318YF S68G, K102Q, K103R, K104KR, K122E, I135T, E138A, I202V, A272P, K281KR, A288S, V292I, I293V, S322T, P345Q, A376S, T386I, K390R  
>4191-30430| codons 1-399
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEKEGKISKIGPENPYNTPV
FAIKKKGGTGWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKQRRSVTVLDVGDAYFSVPL
DEDFRKYTAFTIPSTNNATPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIDI
YQYVDDLYVGSDLEIGQHRTKVEELRQHLWRWGFYTPDKKHQKEPPFLWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCRLLRGTKSLTEIVPLTEEAE
LELAENREILKEPVHGVFYDPTKDLIAEIQKQGQGQWTYQIYQEQFKNLKTGKYARMRGA
HTNDVKQLTEAVQKISTESIVIWGKIPKFRLPIQKETWE

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006