<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-4189 4189-30514 Germany 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, T69D, L210W, T215Y V75M, K219KN K101E, G190A V108I E28K, K32E, V35I, E40F, K43E, V60I, R83K, V118I, D121Y, K122E, I135T, S162C, R172K, I178L, V189VI, G196E, E203K, E204D, Q207E, R211K, K223Q, L228H, A272P, T286A, E297A, S322T, D324E, K350R, G359S, A371V, T377L, K390R, E399D  
>4189-30514| codons 1-399
PISPIETVPVKLKPGMDGPKVKQWPLTKEKIEALIEICTFLEEEGKISKIGPENPYNTPI
FAIKKKNSDKWRKLMDFRELNKKTQDFWEVQLGIPHPAGLEKKKSVTILDVGDAYFSIPL
YEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQCSMTKILEPFKKQNPDLVI
YQYMDDLYIASDLEIEQHRTKIKDLREHLWKWGFYTPDNKHQQEPPFHWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGAKALTEVIPLTAEAE
LELAENREILKEPVHGVYYDPTKELIAEIQKQGQGQWTYQIYQEPFKNLRTGKYARMRSA
HTNDVKQLTEVVQKIALESIVIWGKTPKFRLPIQKETWD

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46L, I54V, I84V, L90M L10F, V11I, G73S A22V, E35D, M36I, K55KR, I62V, L63P, C67F, A71V, I72L, N83S, I85V, T91S  
>4189-30514| codons 1-99
PQITLWQRPFITIKIGGQLKEVLLDTGADDTVLEDINLPGRWKPKLIGGIGGFVRVRQYD
QVPIEIFGHKVLSTVLVGPTPVSVVGRNLMSQIGCTLNF

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006