Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-4189 | 4189-30514 | Germany | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, I54V, I84V, L90M | L10F, V11I, G73S | A22V, E35D, M36I, K55KR, I62V, L63P, C67F, A71V, I72L, N83S, I85V, T91S |
| >4189-30514| codons 1-99 PQITLWQRPFITIKIGGQLKEVLLDTGADDTVLEDINLPGRWKPKLIGGIGGFVRVRQYD QVPIEIFGHKVLSTVLVGPTPVSVVGRNLMSQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, V75M, L210W, T215Y | K219KN | K101E, G190A | V108I | E28K, K32E, V35I, E40F, K43E, V60I, R83K, V118I, D121Y, K122E, I135T, S162C, R172K, I178L, V189VI, G196E, E203K, E204D, Q207E, R211K, K223Q, L228H, A272P, T286A, E297A, S322T, D324E, K350R, G359S, A371V, T377L, K390R, E399D |
| >4189-30514| codons 1-399 PISPIETVPVKLKPGMDGPKVKQWPLTKEKIEALIEICTFLEEEGKISKIGPENPYNTPI FAIKKKNSDKWRKLMDFRELNKKTQDFWEVQLGIPHPAGLEKKKSVTILDVGDAYFSIPL YEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQCSMTKILEPFKKQNPDLVI YQYMDDLYIASDLEIEQHRTKIKDLREHLWKWGFYTPDNKHQQEPPFHWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGAKALTEVIPLTAEAE LELAENREILKEPVHGVYYDPTKELIAEIQKQGQGQWTYQIYQEPFKNLRTGKYARMRSA HTNDVKQLTEVVQKIALESIVIWGKTPKFRLPIQKETWD |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |