<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-4188 4188-30403 Germany 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, T69DN, K70KR, L74I, M184MV, T215F V75S, K219Q K103S, G190A K238T V35I, K43Q, I94IL, K122P, I142IL, S162DN, K166KR, D177E, I178F, G196E, I202IV, E203K, Q207D, H208Y, L210F, R211K, D218E, L228H, V245E, A272P, Q278H, I293V, E297R, I329L, Q334E, R356K, M357T, A360V, A376T, K390R, Q394L, E399D  
>4188-30403| codons 1-399
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALIEICTELEQEGKISKIGPENPYNTPV
FAIKKKNSNRWRKISDFRELNKRTQDFWEVQLGLPHPAGLKKSKSVTVLDVGDAYFSVPL
DPDFRKYTAFTIPSINNETPGLRYQYNVLPQGWKGSPAIFQNSMTRILEPFRKQNPEFVI
YQYVDDLYVASDLEIEQHRTKVKELRDYLFKWGFFTPEQKHQKEPPFHWMGYELHPDTWT
VQPIELPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKHLCKLLRGTKALTEVVPLTREAE
LELAENREILKEPVHGVYYDPSKDLIAELQKQGEGQWTYQIYQEPFKNLKTGKYAKTRGV
HTNDVKQLTEAVQKITTESIVIWGKTPKFRLPILKETWD

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I, I54M, L76V, I84V, L90M L10F, V11I, L89V I13V, I15IV, L19P, K20IV, E34KR, E35D, M36I, R41K, I62V, L63P, A71V  
>4188-30403| codons 1-99
PQITLWQRPFITVKVGGQPVEALLDTGADDTVLRDINLPGKWKPKIIGGIGGFMKVRQYD
QVPIEICGHKVIGTVVVGPTPVNVIGRNVMTQIGCTLNF

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006