Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-4188 | 4188-30403 | Germany | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69DN, K70KR, L74I, M184MV, T215F | V75S, K219Q | K103S, G190A | K238T | V35I, K43Q, I94IL, K122P, I142IL, S162DN, K166KR, D177E, I178F, G196E, I202IV, E203K, Q207D, H208Y, L210F, R211K, D218E, L228H, V245E, A272P, Q278H, I293V, E297R, I329L, Q334E, R356K, M357T, A360V, A376T, K390R, Q394L, E399D |
| >4188-30403| codons 1-399 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALIEICTELEQEGKISKIGPENPYNTPV FAIKKKNSNRWRKISDFRELNKRTQDFWEVQLGLPHPAGLKKSKSVTVLDVGDAYFSVPL DPDFRKYTAFTIPSINNETPGLRYQYNVLPQGWKGSPAIFQNSMTRILEPFRKQNPEFVI YQYVDDLYVASDLEIEQHRTKVKELRDYLFKWGFFTPEQKHQKEPPFHWMGYELHPDTWT VQPIELPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKHLCKLLRGTKALTEVVPLTREAE LELAENREILKEPVHGVYYDPSKDLIAELQKQGEGQWTYQIYQEPFKNLKTGKYAKTRGV HTNDVKQLTEAVQKITTESIVIWGKTPKFRLPILKETWD |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54M, L76V, I84V, L90M | L10F, V11I, L89V | I13V, I15IV, L19P, K20IV, E34KR, E35D, M36I, R41K, I62V, L63P, A71V |
| >4188-30403| codons 1-99 PQITLWQRPFITVKVGGQPVEALLDTGADDTVLRDINLPGKWKPKIIGGIGGFMKVRQYD QVPIEICGHKVIGTVVVGPTPVNVIGRNVMTQIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |