Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-4186 | 4186-30408 | Germany | 2003 | HIV1 | A | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I54V, V82A | L24I, L33I, Q58E, N83D | L10I, I13V, G16E, K20R, A22V, E35D, M36I, N37D, R41K, L63T, H69K, I72V, T74A, L89M, T91V, I93L |
| >4186-30408| codons 1-99 PQITLWQRPIVTVKIEGQLREVLIDTGADDTVIEDIDLPGKWKPKMIGGIGGFVKVREYD QITIEICGKKAVGAVLVGPTPADIIGRNMLVQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, L74LI, M184V, T215Y | V35T, V118VI, D121H, K122E, D123S, K173KN, D177E, I178L, T200K, Q207K, R211T, V245K, S251H, T286A, E291D, V292I, I293V, E297R, A304E, E312N, G335D, R356K, M357K, G359S, A376S, T386I, K390R |
| >4186-30408| codons 1-399 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTEICTELEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKIVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSIPL HESFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRNQNPELVI YQYVDDLYVGSDLEIGQHRKKIEELRKHLLTWGFYTPDKKHQKEPPFLWMGYELHPDKWT VQPIKLPEKDHWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGAKALTDIVPLTREAE LELEENREILKNPVHGVYYDPSKDLIAEIQKQGQDQWTYQIYQEPFKNLKTGKYAKKRSA HTNDVKQLTEAVQKISTESIVIWGKIPKFRLPIQKETWE |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |