<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-4186 4186-30408 Germany 2003 HIV1 A Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
I54V, V82A L24I, L33I, Q58E, N83D L10I, I13V, G16E, K20R, A22V, E35D, M36I, N37D, R41K, L63T, H69K, I72V, T74A, L89M, T91V, I93L  
>4186-30408| codons 1-99
PQITLWQRPIVTVKIEGQLREVLIDTGADDTVIEDIDLPGKWKPKMIGGIGGFVKVREYD
QITIEICGKKAVGAVLVGPTPADIIGRNMLVQLGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, L74LI, M184V, T215Y       V35T, V118VI, D121H, K122E, D123S, K173KN, D177E, I178L, T200K, Q207K, R211T, V245K, S251H, T286A, E291D, V292I, I293V, E297R, A304E, E312N, G335D, R356K, M357K, G359S, A376S, T386I, K390R  
>4186-30408| codons 1-399
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTEICTELEKEGKISKIGPENPYNTPV
FAIKKKDSTKWRKIVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSIPL
HESFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRNQNPELVI
YQYVDDLYVGSDLEIGQHRKKIEELRKHLLTWGFYTPDKKHQKEPPFLWMGYELHPDKWT
VQPIKLPEKDHWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGAKALTDIVPLTREAE
LELEENREILKNPVHGVYYDPSKDLIAEIQKQGQDQWTYQIYQEPFKNLKTGKYAKKRSA
HTNDVKQLTEAVQKISTESIVIWGKIPKFRLPIQKETWE

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006