Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-4185 | 4185-30407 | Germany | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41ML, L74LV, M184MV, L210LW, T215TNSY | D67DG, K219KDEN | Y181C | V179D | K20KR, V35VI, S68G, K103KR, K122KE, I135R, I178IM, G196E, T200A, V245M, A272P, K277KR, E297A, I326V, I329L, F346Y, R356RK, M357I, E370D, A376S, T377V, T386I |
| >4185-30407| codons 1-400 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALIEICTELEKEGKISKIGPENPYNTPV FAIKKKGGTKWRKVVDFRELNKRTQDFWEVQLGIPHPAGLKKRKSVTVLDVGDAYFSVPL DEDFRKYTAFTIPSRNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDMDI CQYVDDLYVGSDLEIEQHRAKIEELRQHLWRWGFYTPDNKHQKEPPFLWMGYELHPDKWT VQPIMLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGTKALTEVIPLTAEAE LELAENREILKEPVHGVYYDPSKDLVAELQKQGQGQWTYQIYQEPYKNLKTGKYAKIRGA HTNDVKQLTDAVQKISVESIVIWGKIPKFKLPIQKETWEA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32VI, I47IV, I54IM, L90LM | L10LF, Q58QE, L89LV | T12P, I13V, K14R, K20KT, E34EQ, M36I, N37S, I62V, L63P, H69Q, A71AV |
| >4185-30407| codons 1-99 PQITLWQRPFVPVRIGGQLTEALLDTGADDTILQEISLPGRWKPKMVGGIGGFMKVREYD QVPIEICGQKVIGTVLVGPTPVNIIGRNVMTQIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |