<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-4185 4185-30407 Germany 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41ML, L74LV, M184MV, L210LW, T215TNSY D67DG, K219KDEN Y181C V179D K20KR, V35VI, S68G, K103KR, K122KE, I135R, I178IM, G196E, T200A, V245M, A272P, K277KR, E297A, I326V, I329L, F346Y, R356RK, M357I, E370D, A376S, T377V, T386I  
>4185-30407| codons 1-400
PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALIEICTELEKEGKISKIGPENPYNTPV
FAIKKKGGTKWRKVVDFRELNKRTQDFWEVQLGIPHPAGLKKRKSVTVLDVGDAYFSVPL
DEDFRKYTAFTIPSRNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDMDI
CQYVDDLYVGSDLEIEQHRAKIEELRQHLWRWGFYTPDNKHQKEPPFLWMGYELHPDKWT
VQPIMLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGTKALTEVIPLTAEAE
LELAENREILKEPVHGVYYDPSKDLVAELQKQGQGQWTYQIYQEPYKNLKTGKYAKIRGA
HTNDVKQLTDAVQKISVESIVIWGKIPKFKLPIQKETWEA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
V32VI, I47IV, I54IM, L90LM L10LF, Q58QE, L89LV T12P, I13V, K14R, K20KT, E34EQ, M36I, N37S, I62V, L63P, H69Q, A71AV  
>4185-30407| codons 1-99
PQITLWQRPFVPVRIGGQLTEALLDTGADDTILQEISLPGRWKPKMVGGIGGFMKVREYD
QVPIEICGQKVIGTVLVGPTPVNIIGRNVMTQIGCTLNF

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006