Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-4184 | 4184-30403 | Germany | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L74I, V75T, M184V, L210W, T215Y | K219Q | K101E, Y181C, G190A | A98G, V108I | K20R, K43KE, V106I, V111I, K122E, D123E, D177E, H208Y, R211K, D218E, L228LH, K277R, T286A, I293IV, E297K, Q334L, A355S, G359GS, A376AS, T386TI, K390R | E40E* |
| >4184-30403| codons 1-399 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALVEICT*LEEEGKISKIGPENPYNTPV FAIKKKNSTKWRKITDFRELNKRTQDFWEVQLGIPHPGGLEKKKSITILDIGDAYFSVPL DEEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPEIVI CQYVDDLYVASDLEIGQHRTKIEELRQYLWKWGFYTPEQKHQKEPPFHWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVRQLCKLLRGAKALTEVVPLTKEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGLGQWTYQIYQEPFKNLKTGKYSRMRSA HTNDVKQLTEAVQKISTESIVIWGKIPKFRLPIQKETWE |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32I, M46I, I47V, I54M, L90M | L33F, F53L, G73S | L10I, E34Q, N37S, D60E, L63P, I66V, A71V, V77I |
| >4184-30403| codons 1-99 PQITLWQRPIVTIKIGGQLKEALLDTGADDTIFQEMSLPGRWKPKIVGGIGGLMKVRQYE QIPIEVCGHKVISTVLIGPTPVNIIGRNLMTQIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |