<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-4184 4184-30403 Germany 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, L74I, M184V, L210W, T215Y V75T, K219Q K101E, Y181C, G190A A98G, V108I K20R, K43KE, V106I, V111I, K122E, D123E, D177E, H208Y, R211K, D218E, L228LH, K277R, T286A, I293IV, E297K, Q334L, A355S, G359GS, A376AS, T386TI, K390R E40E*
>4184-30403| codons 1-399
PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALVEICT*LEEEGKISKIGPENPYNTPV
FAIKKKNSTKWRKITDFRELNKRTQDFWEVQLGIPHPGGLEKKKSITILDIGDAYFSVPL
DEEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPEIVI
CQYVDDLYVASDLEIGQHRTKIEELRQYLWKWGFYTPEQKHQKEPPFHWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVRQLCKLLRGAKALTEVVPLTKEAE
LELAENREILKEPVHGVYYDPSKDLIAEIQKQGLGQWTYQIYQEPFKNLKTGKYSRMRSA
HTNDVKQLTEAVQKISTESIVIWGKIPKFRLPIQKETWE

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
V32I, M46I, I47V, I54M, L90M L33F, F53L, G73S L10I, E34Q, N37S, D60E, L63P, I66V, A71V, V77I  
>4184-30403| codons 1-99
PQITLWQRPIVTIKIGGQLKEALLDTGADDTIFQEMSLPGRWKPKIVGGIGGLMKVRQYE
QIPIEVCGHKVISTVLIGPTPVNIIGRNLMTQIGCTLNF

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006