<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-4183 4183-30403 Germany 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, M184V, L210W, T215Y K219N   A98G T39AE, E44D, V118I, K122E, D123N, I142T, Q174K, V179I, T200A, E203D, H208Y, R211K, A272P, K277R, I293V, E297T, I329L, G333E, A360T, T369V, T386I, K390R, E399D  
>4183-30403| codons 1-399
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICEELEKDGKISKIGPENPYNTPV
FAIKKKNSTKWRKLVDFRELNKRTQDFWEVQLGIPHPGGLKKKKSVTVLDVGDAYFSIPL
DENFRKYTAFTIPSINNETPGTRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKKNPDIII
YQYVDDLYVGSDLEIGQHRAKIDELRQYLWKWGFYTPDNKHQKEPPFLWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGTKALTEVVPLTTEAE
LELAENREILKEPVHGVYYDPSKDLIAELQKQEQGQWTYQIYQEPFKNLKTGKYARMRGT
HTNDVKQLVEAVQKIATESIVIWGKIPKFRLPIQKETWD

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I, I54V, I84V, L90M L10F, L89V T4S, I13IV, G16A, E35D, N37H, D60E, I62V, L63P, A71V, P79A, T91S, I93L  
>4183-30403| codons 1-99
PQISLWQRPFVTVKIAGQLKEALLDTGADDTVLEDMHLPGRWKPKIIGGIGGFVKVRQYE
QVPIEICGHKVIGTVLVGATPVNVIGRNVMSQLGCTLNF

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006