Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-4183 | 4183-30403 | Germany | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, I84V, L90M | L10F, L89V | T4S, I13IV, G16A, E35D, N37H, D60E, I62V, L63P, A71V, P79A, T91S, I93L |
| >4183-30403| codons 1-99 PQISLWQRPFVTVKIAGQLKEALLDTGADDTVLEDMHLPGRWKPKIIGGIGGFVKVRQYE QVPIEICGHKVIGTVLVGATPVNVIGRNVMSQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, M184V, L210W, T215Y | K219N | A98G | T39AE, E44D, V118I, K122E, D123N, I142T, Q174K, V179I, T200A, E203D, H208Y, R211K, A272P, K277R, I293V, E297T, I329L, G333E, A360T, T369V, T386I, K390R, E399D |
| >4183-30403| codons 1-399 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICEELEKDGKISKIGPENPYNTPV FAIKKKNSTKWRKLVDFRELNKRTQDFWEVQLGIPHPGGLKKKKSVTVLDVGDAYFSIPL DENFRKYTAFTIPSINNETPGTRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKKNPDIII YQYVDDLYVGSDLEIGQHRAKIDELRQYLWKWGFYTPDNKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGTKALTEVVPLTTEAE LELAENREILKEPVHGVYYDPSKDLIAELQKQEQGQWTYQIYQEPFKNLKTGKYARMRGT HTNDVKQLVEAVQKIATESIVIWGKIPKFRLPIQKETWD |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |