Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-4181 | 4181-30623 | Germany | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| T69G_SG, L210W, T215FY | A62V, V75I | K103N, Y181C, G190A | A98G | K20R, K64R, K122E, S163A, T200A, Q207E, L228H, V245E, A272P, K277R, L283I, A288S, I293V, E297A, D324E, G335C, M357V, T369S, A371V, I375V, K390R |
| >4181-30623| codons 1-399 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FVIRKKDSGKWRKLIDFRELNKRTQDFWEVQLGIPHPGGLKKNKSVTVLDVGDAYFSVPL DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSAMTKILEPFRKQNPDIVI CQYMDDLYVASDLEIGQHRAKIEELREHLWRWGFYTPDKKHQKEPPFHWMGYELHPDKWT VQPIELPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLIRGTKSLTEVVPLTAEAE LELAENREILKEPVHGVYYDPSKELIAEIQKQGQCQWTYQIYQEPFKNLKTGKYARVRGA HTNDVKQLSEVVQKVATESIVIWGKTPKFRLPIQKETWE |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I47V, I54M, L76V, I84V, L90M | V11I, G73T, L89V | L10I, I15V, G16A, K20I, M36I, N37D, L63P, A71V, V82I, I85V |
| >4181-30623| codons 1-99 PQITLWQRPIITIKVAGQLIEALLDTGADDTVLEEIDLPGRWKPKIVGGIGGFMKVRQYD QIPIEICGHKVITTVVVGPTPINVVGRNVMTQIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |