Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-4180 | 4180-30611 | Germany | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| G48GA, I54V, V82A, L90M | K43KT, G73GS | L10I, I13V, L19I, K20R, E35D, M36I, N37D, D60E, I62V, L63P, A71V, T74S, I93L |
| >4180-30611| codons 1-99 PQITLWQRPIVTVKIGGQIREALLDTGADDTVLEDIDLPGRWTPKMIAGIGGFVKVRQYE QVPIEICGHKVISSVLVGPTPANIIGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, T69D, K70R, T215F | K219Q | K103N, G190A | V35T, T39A, K122E, I135T, I142V, T200TI, F214L, L228N, V245T, R284K, T286A, I293V, P294V, E297R, M357MI, R358K, A376T, T386A, K390R, Q394L |
| >4180-30611| codons 1-400 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTEICAEMEKEGKISKIGPENPYNTPV FAIKKKNSDRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL DEDFRKYTAFTIPSTNNETPGVRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYMDDLYVASDLEIGQHRIKIEELRQHLLRWGLFTPDQKHQKEPPFNWMGYELHPDKWT VQPITLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLKGAKALTEVVVLTREAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARIKGA HTNDVKQLTEAVQKITTESIVIWGKAPKFRLPILKETWEA |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |