<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-4179 4179-30428 Germany 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I, I54IV, L76LV, V82VAIT, L90M G73GS L10I, I13IV, I15IV, L19LIPT, K20I, E35D, M36I, N37D, I62V, L63P, H69HY, A71V I72I*KL
>4179-30428| codons 1-99
PQITLWQRPIVTVKVGGQTIEALLDTGADDTVLEDIDLPGRWKPKIIGGIGGFVKVRQYD
QVPIEICGYKVLSTVVVGPTPTNIIGRNLMTQIGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, M184V, L210W, T215Y A62AV, K219N Y188L Y318F E6DN, T39A, K43E, E44D, K102KQ, V106I, V118I, K122E, D123DN, S162Y, V179I, V189I, E203K, Q207E, H208Y, R211K, K223E, L228H, A272P, E291D, I326IL, Q334LV, R356K, M357R, G359S, T369V, T377M, K390R  
>4179-30428| codons 1-400
PISPINTVPVKLKPGMDGPKVKQWPLTEEKIKALVEICAELEEDGKISKIGPENPYNTPV
FVIKKKNSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKQKKSITVLDVGDAYFSIPL
DENFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQYSMTKILEPFRKQNPDIII
YQYVDDLLIGSDLEIGQHRTKIKELREYLWKWGFYTPDNKHQEEPPFHWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKALTDVIPLTEEAE
LELAENREILKEPVHGVFYDPSKDLLAEIQKQGVGQWTYQIYQEPFKNLKTGKYAKRRSA
HTNDVKQLVEAVQKIAMESIVIWGKTPKFRLPIQKETWEA

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006