Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-4179 | 4179-30428 | Germany | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54IV, L76LV, V82VAIT, L90M | G73GS | L10I, I13IV, I15IV, L19LIPT, K20I, E35D, M36I, N37D, I62V, L63P, H69HY, A71V | I72I*KL |
| >4179-30428| codons 1-99 PQITLWQRPIVTVKVGGQTIEALLDTGADDTVLEDIDLPGRWKPKIIGGIGGFVKVRQYD QVPIEICGYKVLSTVVVGPTPTNIIGRNLMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, M184V, L210W, T215Y | A62AV, K219N | Y188L | Y318F | E6DN, T39A, K43E, E44D, K102KQ, V106I, V118I, K122E, D123DN, S162Y, V179I, V189I, E203K, Q207E, H208Y, R211K, K223E, L228H, A272P, E291D, I326IL, Q334LV, R356K, M357R, G359S, T369V, T377M, K390R |
| >4179-30428| codons 1-400 PISPINTVPVKLKPGMDGPKVKQWPLTEEKIKALVEICAELEEDGKISKIGPENPYNTPV FVIKKKNSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKQKKSITVLDVGDAYFSIPL DENFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQYSMTKILEPFRKQNPDIII YQYVDDLLIGSDLEIGQHRTKIKELREYLWKWGFYTPDNKHQEEPPFHWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKALTDVIPLTEEAE LELAENREILKEPVHGVFYDPSKDLLAEIQKQGVGQWTYQIYQEPFKNLKTGKYAKRRSA HTNDVKQLVEAVQKIAMESIVIWGKTPKFRLPIQKETWEA |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |