Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-4178 | 4178-30627 | Germany | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, K70R, L74I, M184V, T215F | V75A, K219Q | V106M, G190GA | F227L | T7TP, P9S, T39E, E44D, T69N, I94L, V118I, D121DH, D123E, I135T, S162A, D177E, V179VI, T200S, E203ED, Q207E, H208Y, R211K, F214L, D218E, K249Q, A272P, A288S, E297K, Q334P, G335S, M357T, G359S, A371V, T386I | I37IL |
| >4178-30627| codons 1-399 PISPIEPVSVKLKPGMDGPKVKQWPLTEEKIKALVELCEELEKDGKISKIGPENPYNTPV FAIKKKNSNRWRKIADFRELNKRTQDFWEVQLGLPHPAGLKKKKSMTVLDVGDAYFSIPL HKEFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQASMTKILEPFRKQNPEIII YQYVDDLYVASDLEIGQHRSKIDELREYLLKWGLFTPEQKHQKEPPLLWMGYELHPDKWT VQPIVLPEQDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKSLTEVIPLTKEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGPSQWTYQIYQEPFKNLKTGKYARTRSA HTNDVKQLTEVVQKIATESIVIWGKIPKFKLPIQKETWE |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, I84V, L90M | L10F, Q58E, G73T | T4TA, I13M, L19I, K20I, M36MI, K55R, D60E, L63P, I64V, I66V, C67F, H69HR, A71V, I72L, P79A, I93L |
| >4178-30627| codons 1-99 PQIALWQRPFVTMKIGGQIIEALLDTGADDTVLEEINLPGRWKPKIIGGIGGFVRVREYE QIPVEVFGRKVLTTVLVGATPVNVIGRNLMTQLGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |