<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-4177 4177-30507 Germany 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I, I54V, V82A L24I, Q58E, L76LI L10V, I15V, K20R, E35D, M36I, N37D, D60E, L63P, I64V, K70KT, A71V, T91A, I93L  
>4177-30507| codons 1-99
PQITLWQRPVVTIKVGGQLREALIDTGADDTVLEDIDLPGRWKPKIIGGIGGFVKVREYE
QIPVEICGHTVIGTVIVGPTPANIIGRNLLAQLGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, L74V, L210W, T215Y N348I K103KN, Y181C, G190GRS V179VF E6EK, K20R, V60I, A98S, V118VI, K122E, I135T, K166KR, E203K, Q207QE, R211RK, F214FL, A272P, K277R, P294T, E297K, Q334E, G359S, T369TI, K390R  
>4177-30507| codons 1-399
PISPIKTVPVKLKPGMDGPRVKQWPLTEEKIKALVEICTELEKEGKISKIGPENPYNTPI
FAIKKKNSTKWRKVVDFRELNKRTQDFWEVQLGIPHPSGLKKNKSVTVLDVGDAYFSIPL
DEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTRILEPFRKQNPDIFI
CQYMDDLYVSSDLEIGQHRTKIKELREHLWKWGLYTPDKKHQKEPPFLWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGTKALTEVITLTKEAE
LELAENREILKEPVHGVYYDPSKDLIAEIQKQGEGQWTYQIYQEPFKILKTGKYARMRSA
HTNDVKQLIEAVQKIATESIVIWGKTPKFRLPIQKETWE

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006