Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-4175 | 4175-30502 | Germany | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32I, M46I, I47V, V82A | L24I, L33F, Q58E | L10I, L19I, E35D, L63LP, I64IV, I72V |
| >4175-30502| codons 1-99 PQITLWQRPIVTIKIGGQIKEALIDTGADDTIFEDMNLPGRWKPKIVGGIGGFIKVREYD QIPVEICGHKAVGTVLVGPTPANIIGRNLLTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| K70R, M184V, T215F | D67H, K219E | Y181C | V35I, K102Q, D123E, I142V, T200I, L210F, R211K, P294T, E297K, Q334QE, A376S, T377Q, K390R |
| >4175-30502| codons 1-399 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALIEICTEMEKEGKISKIGPENPYNTPV FAIKKKHSTRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKQKKSVTVLDVGDAYFSVPL DKEFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI CQYVDDLYVGSDLEIGQHRIKIEELRQHLFKWGFFTPDEKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGTKALTEVITLTKEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGEGQWTYQIYQEPFKNLKTGKYARMRGA HTNDVKQLTEAVQKISQESIVIWGKTPKFRLPIQKETWE |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |