<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-4172 4172-30506 Germany 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, L74V, M184MV, T215Y   Y188L K101KN, V179VD K20R, T39A, K122E, I135T, S162C, V189I, Q197K, H208L, R211K, K223Q, V245T, K277R, I293V, E297K, I329V, Q334L, M357MI, R358K, K390R  
>4172-30506| codons 1-400
PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALVEICAELEKEGKISKIGPENPYNTPV
FAIKKKDSTKWRKVVDFRELNKRTQDFWEVQLGIPHPAGLNKKKSVTVLDVGDAYFSVPL
DEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQCSMTKILEPFRKQNPDIDI
YQYVDDLLIGSDLEIGKHRTKIEELRQLLLKWGFYTPDKKHQQEPPFLWMGYELHPDKWT
VQPITLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVRQLCKLLRGTKALTEVVPLTKEAE
LELAENREILKEPVHGVYYDPSKDLIAEVQKQGLGQWTYQIYQEPFKNLKTGKYARIKGA
HTNDVKQLTEAVQKIATESIVIWGKTPKFRLPIQKETWEA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
V32VIM, M46I, I47V, I54L, V82A, I84V, L90M L33F, F53L, Q58E L10IV, I13V, G16A, E34Q, N37D, L63P, A71V, I72T, V77VI, I85IV, L89LM, I93L  
>4172-30506| codons 1-99
PQITLWQRPVVTVKIAGQLKEALLDTGADDTMFQEMDLPGRWKPKIVGGIGGLLKVREYD
QIPIEICGHKVTGTVLIGPTPANVVGRNMMTQLGCTLNF

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006