Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-4172 | 4172-30506 | Germany | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32VIM, M46I, I47V, I54L, V82A, I84V, L90M | L33F, F53L, Q58E | L10IV, I13V, G16A, E34Q, N37D, L63P, A71V, I72T, V77VI, I85IV, L89LM, I93L |
| >4172-30506| codons 1-99 PQITLWQRPVVTVKIAGQLKEALLDTGADDTMFQEMDLPGRWKPKIVGGIGGLLKVREYD QIPIEICGHKVTGTVLIGPTPANVVGRNMMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, L74V, M184MV, T215Y | Y188L | K101KN, V179VD | K20R, T39A, K122E, I135T, S162C, V189I, Q197K, H208L, R211K, K223Q, V245T, K277R, I293V, E297K, I329V, Q334L, M357MI, R358K, K390R |
| >4172-30506| codons 1-400 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALVEICAELEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKVVDFRELNKRTQDFWEVQLGIPHPAGLNKKKSVTVLDVGDAYFSVPL DEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQCSMTKILEPFRKQNPDIDI YQYVDDLLIGSDLEIGKHRTKIEELRQLLLKWGFYTPDKKHQQEPPFLWMGYELHPDKWT VQPITLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVRQLCKLLRGTKALTEVVPLTKEAE LELAENREILKEPVHGVYYDPSKDLIAEVQKQGLGQWTYQIYQEPFKNLKTGKYARIKGA HTNDVKQLTEAVQKIATESIVIWGKTPKFRLPIQKETWEA |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |