Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-4169 | 4169-30409 | Germany | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41ML, T69S_SS, L210W, T215CY | Y188L | P4S, E6D, V35VI, V106I, K122E, I135V, K173Q, Q174QK, T200I, Q207E, R211K, E224K, V245EK, K275KR, L283I, I293V, E297K, M357MR, A371V |
| >4169-30409| codons 1-400 PISSIDTVPVKLKPGMDGPKVKQWPLTEEKIKALIEICTELEKEGKISKIGPENPYNTPV FAIKKKDSSKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSITVLDVGDAYFSVPL DEDFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRQKNPDIVI YQYMDDLLVGSDLEIGQHRIKIEELREHLWKWGFYTPDKKHQKKPPFLWMGYELHPDKWT VQPIKLPEKDSWTVNDIQKLVGKLNWASQIYAGIRVKQLCKLIRGTKALTEVVPLTKEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARRRGA HTNDVKQLTEVVQKIATESIVIWGKTPKFKLPIQKETWEA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I54V, L76V, V82F, L90M | L33F | L10I, I13V, K14R, M36I, I62V, L63P, I64V, A71V, I93L |
| >4169-30409| codons 1-99 PQITLWQRPIVTVRIGGQLKEALLDTGADDTVFEEINLPGRWKPKMIGGIGGFVKVRQYD QVPVEICGHKVIGTVVVGPTPFNIIGRNLMTQLGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |