Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-4167 | 4167-30423 | Germany | 2003 | HIV1 | CRF02_AG | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, I54V, I84V | L10I, I13A, L19P, K20I, A22V, E35D, M36I, N37S, R41K, D60E, I66F, H69K, A71V, L89I, T91S, Q92K |
| >4167-30423| codons 1-99 PQITLWQRPIVTAKIGGQPIEVLLDTGADDTVLEDISLPGKWKPKLIGGIGGFVKVRQYE QILIEFCGKKVIGTVLVGPTPVNVIGRNILSKIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, M184V, L210W, T215FY | A98G | V35T, T39N, V60I, V118I, K122E, D123N, I135V, K173I, Q174K, D177E, T200A, Q207G, R211K, V245K, D250E, K277R, T286A, E291D, V292I, I293V, E297EA, D324E, I326V, G335D, R356K, M357R, R358K, G359S, K366KR, A371V, I375V, T377Q, K395R |
| >4167-30423| codons 1-400 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTEICNELEKEGKISKIGPENPYNTPI FAIKKKNSTKWRKLVDFRELNKRTQDFWEVQLGIPHPGGLKKKKSVTVLDVGDAYFSIPL DENFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRIKNPEIVI YQYVDDLYVGSDLEIGQHRAKIEELRGHLWKWGFYTPDKKHQKEPPFLWMGYELHPDKWT VQPIKLPEKESWTVNDIQKLVGKLNWASQIYAGIKVRQLCKLLRGAKALTDIVPLTAEAE LELAENREILKEPVHGVYYDPSKELVAEIQKQGQDQWTYQIYQEPFKNLKTGKYAKRKSA HTNDVRQLTEVVQKVAQESIVIWGKTPKFKLPIQRETWEA |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |