<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-4167 4167-30423 Germany 2003 HIV1 CRF02_AG Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46L, I54V, I84V   L10I, I13A, L19P, K20I, A22V, E35D, M36I, N37S, R41K, D60E, I66F, H69K, A71V, L89I, T91S, Q92K  
>4167-30423| codons 1-99
PQITLWQRPIVTAKIGGQPIEVLLDTGADDTVLEDISLPGKWKPKLIGGIGGFVKVRQYE
QILIEFCGKKVIGTVLVGPTPVNVIGRNILSKIGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, M184V, L210W, T215FY     A98G V35T, T39N, V60I, V118I, K122E, D123N, I135V, K173I, Q174K, D177E, T200A, Q207G, R211K, V245K, D250E, K277R, T286A, E291D, V292I, I293V, E297EA, D324E, I326V, G335D, R356K, M357R, R358K, G359S, K366KR, A371V, I375V, T377Q, K395R  
>4167-30423| codons 1-400
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTEICNELEKEGKISKIGPENPYNTPI
FAIKKKNSTKWRKLVDFRELNKRTQDFWEVQLGIPHPGGLKKKKSVTVLDVGDAYFSIPL
DENFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRIKNPEIVI
YQYVDDLYVGSDLEIGQHRAKIEELRGHLWKWGFYTPDKKHQKEPPFLWMGYELHPDKWT
VQPIKLPEKESWTVNDIQKLVGKLNWASQIYAGIKVRQLCKLLRGAKALTDIVPLTAEAE
LELAENREILKEPVHGVYYDPSKELVAEIQKQGQDQWTYQIYQEPFKNLKTGKYAKRKSA
HTNDVRQLTEVVQKVAQESIVIWGKTPKFKLPIQRETWEA

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006