<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-4165 4165-30410 Germany 2003 HIV1 D Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46MI, I54V, V82S L24I L10I, I13V, L19I, K20IM, M36I, R41K, L63P, A71V  
>4165-30410| codons 1-99
PQITLWQRPIVTVKIGGQIMEALIDTGADDTVLEEINLPGKWKPKIIGGIGGFVKVRQYD
QIPIEICGHKVIGTVLVGPTPSNIIGRNLLTQIGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, K70R, T215F K219Q K101E, G190S   V35T, K49R, V60I, T69TN, V90I, A98S, V118I, K122E, I135T, E138A, T165I, E169D, R172RK, D177E, I178L, V179X, Q197E, E203A, Q207E, R211K, F214L, L228H, V245T, D250E, A272P, K277R, T286A, E297KR, I329L, G335D, M357MT, G359S, A376T, S379C, T386A  
>4165-30410| codons 1-399
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTEICTELEKEGKISRIGPENPYNTPI
FAIKKKNSNRWRKLVDFRELNKRTQDFWEIQLGIPHPSGLEKKKSVTVLDVGDAYFSIPL
DEDFRKYTAFTIPSTNNATPGIRYQYNVLPQGWKGSPAIFQSSMIKILDPFKKQNPELXI
YQYMDDLYVSSDLEIGEHRTKIAELREHLLKWGLFTPDQKHQKEPPFHWMGYELHPDKWT
VQPITLPEKESWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGAKALTEVIPLTREAE
LELAENREILKEPVHGVYYDPSKDLIAELQKQGQDQWTYQIYQEPFKNLKTGKYARTRSA
HTNDVKQLTEAVQKITTECIVIWGKAPKFKLPIQKETWE

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006