Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-4164 | 4164-30403 | Germany | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, K70G, M184V | K219Q | K103N, V106A | F227FL | V60I, K122E, D123N, I135T, K173R, Q174K, I202V, Q207E, R211K, F214L, H221Y, A272P, K277R, V317VA, D324E, I329IL, Q334N, E344D, P345L, G359GS, T369V, T386I, K390R, E399D |
| >4164-30403| codons 1-399 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPI FAIKKKNSTGWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSATVLDVGDAYFSVPL DENFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRRKNPDIVI YQYVDDLYVGSDLEIGQHRTKVEELREHLLKWGLTTPDQKYQKEPPLLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGTKALTEVIPLTEEAE LELAENREILKEPVHGAYYDPSKELIAELQKQGNGQWTYQIYQDLFKNLKTGKYARMRSA HTNDVKQLVEAVQKIATESIVIWGKIPKFRLPIQKETWD |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| T12P, L19I, R41K, L63P, I64V, C67W, Q92K |
| >4164-30403| codons 1-99 PQITLWQRPLVPIKIGGQIKEALLDTGADDTVLEEMNLPGKWKPKMIGGIGGFIKVRQYD QIPVEIWGHKAIGTVLVGPTPVNIIGRNLLTKIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |