<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-4162 4162-30402 Germany 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, T69D, L74LI, L210W, T215Y K219R K101E, G190A A98G E28EK, V35IM, T39A, K43Q, V118I, D123E, R211K, V245T, K277R, I293V, E297K, I326V, A355G, R358K, G359S, A371V, I375V E40E*, N137H
>4162-30402| codons 1-400
PISPIETVPVKLKPGMDGPKVKQWPLTKEKIKALMEICA*LEQEGKISKIGPENPYNTPV
FAIKKKNSDKWRKIVDFRELNKRTQDFWEVQLGIPHPGGLEKKKSVTVLDVGDAYFSIPL
DKEFRKYTAFTIPSINHETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI
YQYMDDLYVASDLEIGQHRTKIEELRQHLWKWGFYTPDRKHQKEPPFLWMGYELHPDKWT
VQPITLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVRQLCKLLRGTKALTEVVPLTKEAE
LELAENREILKEPVHGVYYDPSKDLVAEIQKQGQGQWTYQIYQEPFKNLKTGKYGRMKSA
HTNDVKQLTEVVQKVATESIVIWGKTPKFKLPIQKETWEA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I, I54L, V82T, I84V L24I, L33F L10I, T12N, I15V, G16A, L19P, K20T, N37S, R41K, L63P, A71V, T91TS  
>4162-30402| codons 1-99
PQITLWQRPIVNIKVAGQPTEALIDTGADDTVFEEMSLPGKWKPKIIGGIGGFLKVRQYD
QIPIEICGHKVIGTVLVGPTPTNVIGRNLLSQIGCTLNF

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006