<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-4160 4160-30408 Germany 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, T69D, L74V, M184MV, L210W, T215Y K219R L100I, K103N   E6K, T39A, E44D, V118I, K122E, I142V, I178L, E203K, Q207E, H208Y, R211K, K223Q, L228R, A272P, K277R, L283I, T286A, I293V, P294T, E297K, V317A, D324E, I329V, Q334H, R356K, G359S, T369V, A371V, I375V, K390R  
>4160-30408| codons 1-400
PISPIKTVPVKLKPGMDGPKVKQWPLTEEKIKALVEICAELEKDGKISKIGPENPYNTPV
FAIKKKDSDKWRKVVDFRELNKRTQDFWEVQLGIPHPAGIKKNKSVTVLDVGDAYFSIPL
DEDFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDLVI
YQYVDDLYVGSDLEIGQHRTKIKELREYLWKWGFYTPDRKHQQEPPFRWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLIRGAKALTEVVTLTKEAE
LELAENREILKEPVHGAYYDPSKELIAEVQKQGHGQWTYQIYQEPFKNLKTGKYAKMRSA
HTNDVKQLVEVVQKVATESIVIWGKTPKFRLPIQKETWEA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I, I54IV, I84V, L90M L10FI, G73T I15IV, L19Q, K20I, L63P, E65D, H69Q, K70R, A71V, P79D, I93L  
>4160-30408| codons 1-99
PQITLWQRPIVTIKVGGQQIEALLDTGADDTVLEEMNLPGRWKPKIIGGIGGFVKVRQYD
QIPIDICGQRVITTVLVGDTPVNVIGRNLMTQLGCTLNF

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006