Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-4160 | 4160-30408 | Germany | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, T69D, L74V, M184MV, L210W, T215Y | K219R | L100I, K103N | E6K, T39A, E44D, V118I, K122E, I142V, I178L, E203K, Q207E, H208Y, R211K, K223Q, L228R, A272P, K277R, L283I, T286A, I293V, P294T, E297K, V317A, D324E, I329V, Q334H, R356K, G359S, T369V, A371V, I375V, K390R |
| >4160-30408| codons 1-400 PISPIKTVPVKLKPGMDGPKVKQWPLTEEKIKALVEICAELEKDGKISKIGPENPYNTPV FAIKKKDSDKWRKVVDFRELNKRTQDFWEVQLGIPHPAGIKKNKSVTVLDVGDAYFSIPL DEDFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDLVI YQYVDDLYVGSDLEIGQHRTKIKELREYLWKWGFYTPDRKHQQEPPFRWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLIRGAKALTEVVTLTKEAE LELAENREILKEPVHGAYYDPSKELIAEVQKQGHGQWTYQIYQEPFKNLKTGKYAKMRSA HTNDVKQLVEVVQKVATESIVIWGKTPKFRLPIQKETWEA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54IV, I84V, L90M | L10FI, G73T | I15IV, L19Q, K20I, L63P, E65D, H69Q, K70R, A71V, P79D, I93L |
| >4160-30408| codons 1-99 PQITLWQRPIVTIKVGGQQIEALLDTGADDTVLEEMNLPGRWKPKIIGGIGGFVKVRQYD QIPIDICGQRVITTVLVGDTPVNVIGRNLMTQLGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |