Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-4159 | 4159-30825 | Germany | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, I84V | L10F | T4P, I13V, K20T, N37S, L63P, A71V, I72R, P79D, T91S |
| >4159-30825| codons 1-99 PQIPLWQRPFVTVKIGGQLTEALLDTGADDTVLEEMSLPGRWKPKIIGGIGGFVKVRQYD QIPIEICGHKVRGTVLVGDTPVNVIGRNLLSQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, K70R, T215Y | K219Q | K103N | V108I | K173R, R211K, D218E, L228H, E248D, A272P, K277R, S322T, I329L, Q334E |
| >4159-30825| codons 1-399 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEKEGKISKIGPENPYNTPV FAIKKKNSTRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTILDVGDAYFSVPL DKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRRQNPDIVI YQYMDDLYVGSDLEIGQHRTKIEELRQHLLKWGFYTPEQKHQKEPPFHWMGYELHPDKWT VQPIVLPDKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGTKALTEVIPLTEEAE LELAENREILKEPVHGVYYDPTKDLIAELQKQGEGQWTYQIYQEPFKNLKTGKYARMRGA HTNDVKQLTEAVQKIATESIVIWGKTPKFKLPIQKETWE |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |