Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-4157 | 4157-30401 | Germany | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, L74V, M184V, L210W, T215Y | D67DG, K219N | Y181C, G190GS | I31IL, K43E, E44A, S68G, V90VI, V118I, K122E, T165TI, E203Q, Q207D, H208HY, R211RK, F214FL, D250E, A272P, K277R, T286A, E297KR, G333E, R358K, G359S, K366R, A371V, A376S, T386I |
| >4157-30401| codons 1-399 PISPIETVPVKLKPGMDGPKVKQWPLTEEKLKALVEICTELEEAGKISKIGPENPYNTPV FAIKKKGGTKWRKVVDFRELNKRTQDFWEIQLGIPHPAGLKKKKSVTVLDVGDAYFSIPL DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMIKILEPFRKQNPDIVI CQYVDDLYVSSDLEIGQHRTKIQELRDYLWKWGLYTPDNKHQKEPPFLWMGYELHPDKWT VQPIVLPEKESWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGAKALTEVIPLTREAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQEQGQWTYQIYQEPFKNLKTGKYARMKSA HTNDVRQLTEVVQKISTESIVIWGKIPKFKLPIQKETWE |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I84V, L90M | L10F, L33F, G73T | E34Q, N37S, G51A, I62V, L63P, I66L, C67W, V77I, I93L |
| >4157-30401| codons 1-99 PQITLWQRPFVTIKIGGQLKEALLDTGADDTVFQEMSLPGRWKPKIIGGIAGFIKVRQYD QVPIELWGHKAITTVLIGPTPVNVIGRNLMTQLGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |