<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-4157 4157-30401 Germany 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I, I84V, L90M L10F, L33F, G73T E34Q, N37S, G51A, I62V, L63P, I66L, C67W, V77I, I93L  
>4157-30401| codons 1-99
PQITLWQRPFVTIKIGGQLKEALLDTGADDTVFQEMSLPGRWKPKIIGGIAGFIKVRQYD
QVPIELWGHKAITTVLIGPTPVNVIGRNLMTQLGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, L74V, M184V, L210W, T215Y D67DG, K219N Y181C, G190GS   I31IL, K43E, E44A, S68G, V90VI, V118I, K122E, T165TI, E203Q, Q207D, H208HY, R211RK, F214FL, D250E, A272P, K277R, T286A, E297KR, G333E, R358K, G359S, K366R, A371V, A376S, T386I  
>4157-30401| codons 1-399
PISPIETVPVKLKPGMDGPKVKQWPLTEEKLKALVEICTELEEAGKISKIGPENPYNTPV
FAIKKKGGTKWRKVVDFRELNKRTQDFWEIQLGIPHPAGLKKKKSVTVLDVGDAYFSIPL
DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMIKILEPFRKQNPDIVI
CQYVDDLYVSSDLEIGQHRTKIQELRDYLWKWGLYTPDNKHQKEPPFLWMGYELHPDKWT
VQPIVLPEKESWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGAKALTEVIPLTREAE
LELAENREILKEPVHGVYYDPSKDLIAEIQKQEQGQWTYQIYQEPFKNLKTGKYARMKSA
HTNDVRQLTEVVQKISTESIVIWGKIPKFKLPIQKETWE

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006