<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-4156 4156-30328 Germany 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, T69D, L210W, T215Y V75M G190A   E6ED, V35M, K43E, V60I, K102KQ, V118I, K122E, A158S, S162D, V179I, E203ED, R211K, V245VE, I257L, T286TA, I293V, M357T, G359S, A371V, K390R V261VIM
>4156-30328| codons 1-399
PISPIDTVPVKLKPGMDGPKVKQWPLTEEKIKALMEICTELEEEGKISKIGPENPYNTPI
FAIKKKNSDKWRKLMDFRELNKRTQDFWEVQLGIPHPAGLKQKKSVTVLDVGDAYFSIPL
DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPSIFQDSMTKILEPFRKQNPDIII
YQYMDDLYVASDLEIGQHRTKIDELRQHLWKWGFYTPDKKHQKEPPFLWMGYELHPDKWT
VQPIELPEKDSWTVNDLQKLMGKLNWASQIYAGIKVKQLCKLLRGAKALTEVVPLTEEAE
LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARTRSA
HTNDVKQLTEVVQKIATESIVIWGKTPKFRLPIQKETWE

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I, I54V, I84V, L90M L10F, G73C, L89V T4A, I15V, L19LP, K20I, M36I, I62V, I64IV, T74S, I85V, T91S  
>4156-30328| codons 1-99
PQIALWQRPFVTIKVGGQPIEALLDTGADDTVLEEINLPGRWKPKIIGGIGGFVKVRQYD
QVLVEICGHKAICSVLVGPTPVNVVGRNVMSQIGCTLNF

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006