Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-4156 | 4156-30328 | Germany | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, I84V, L90M | L10F, G73C, L89V | T4A, I15V, L19LP, K20I, M36I, I62V, I64IV, T74S, I85V, T91S |
| >4156-30328| codons 1-99 PQIALWQRPFVTIKVGGQPIEALLDTGADDTVLEEINLPGRWKPKIIGGIGGFVKVRQYD QVLVEICGHKAICSVLVGPTPVNVVGRNVMSQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, V75M, L210W, T215Y | G190A | E6ED, V35M, K43E, V60I, K102KQ, V118I, K122E, A158S, S162D, V179I, E203ED, R211K, V245VE, I257L, V261VIM, T286TA, I293V, M357T, G359S, A371V, K390R |
| >4156-30328| codons 1-399 PISPIDTVPVKLKPGMDGPKVKQWPLTEEKIKALMEICTELEEEGKISKIGPENPYNTPI FAIKKKNSDKWRKLMDFRELNKRTQDFWEVQLGIPHPAGLKQKKSVTVLDVGDAYFSIPL DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPSIFQDSMTKILEPFRKQNPDIII YQYMDDLYVASDLEIGQHRTKIDELRQHLWKWGFYTPDKKHQKEPPFLWMGYELHPDKWT VQPIELPEKDSWTVNDLQKLMGKLNWASQIYAGIKVKQLCKLLRGAKALTEVVPLTEEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARTRSA HTNDVKQLTEVVQKIATESIVIWGKTPKFRLPIQKETWE |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |