<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-4154 4154-30328 Germany 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, T69DN, K70R, Q151M, T215F A62V, V75I, F116Y, K219Q Y181C, G190A V108I V35I, T39A, V60I, K101Q, V118I, K122E, D123E, I135T, S162D, K166R, L187F, G196E, F214L, D218E, L228H, A272P, K277R, T286A, I293IV, E297K, V317VA, S322A, M357R, A360T, T386I, K390R  
>4154-30328| codons 1-399
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALIEICAELEKEGKISKIGPENPYNTPI
FVIKKKNSNRWRKLIDFRELNKRTQDFWEVQLGIPHPAGLQKKKSVTILDVGDAYYSIPL
DEEFRKYTAFTIPSTNNETPGIRYQYNVLPMGWKGSPAIFQDSMTRILEPFRKQNPDIVI
CQYMDDFYVASDLEIEQHRTKIEELRQHLLRWGLFTPEQKHQKEPPFHWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGAKALTEVVPLTKEAE
LELAENREILKEPVHGAYYDPAKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARRRGT
HTNDVKQLTEAVQKIATESIVIWGKIPKFRLPIQKETWE

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I, I54V, L76V, V82A, L90M V11VI, L33F, G73S L10I, I13V, K14KR, G16A, N37D, K55R, R57K, L63P, A71V, I72L  
>4154-30328| codons 1-99
PQITLWQRPIITVRIAGQLKEALLDTGADDTVFEEMDLPGRWKPKIIGGIGGFVRVKQYD
QIPIEICGHKVLSTVVVGPTPANIIGRNLMTQIGCTLNF

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006