Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-4154 | 4154-30328 | Germany | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69DN, K70R, Q151M, T215F | A62V, V75I, F116Y, K219Q | Y181C, G190A | V108I | V35I, T39A, V60I, K101Q, V118I, K122E, D123E, I135T, S162D, K166R, L187F, G196E, F214L, D218E, L228H, A272P, K277R, T286A, I293IV, E297K, V317VA, S322A, M357R, A360T, T386I, K390R |
| >4154-30328| codons 1-399 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALIEICAELEKEGKISKIGPENPYNTPI FVIKKKNSNRWRKLIDFRELNKRTQDFWEVQLGIPHPAGLQKKKSVTILDVGDAYYSIPL DEEFRKYTAFTIPSTNNETPGIRYQYNVLPMGWKGSPAIFQDSMTRILEPFRKQNPDIVI CQYMDDFYVASDLEIEQHRTKIEELRQHLLRWGLFTPEQKHQKEPPFHWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGAKALTEVVPLTKEAE LELAENREILKEPVHGAYYDPAKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARRRGT HTNDVKQLTEAVQKIATESIVIWGKIPKFRLPIQKETWE |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, L76V, V82A, L90M | V11VI, L33F, G73S | L10I, I13V, K14KR, G16A, N37D, K55R, R57K, L63P, A71V, I72L |
| >4154-30328| codons 1-99 PQITLWQRPIITVRIAGQLKEALLDTGADDTVFEEMDLPGRWKPKIIGGIGGFVRVKQYD QIPIEICGHKVLSTVVVGPTPANIIGRNLMTQIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |