<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-4153 4153-30326 Germany 2003 HIV1 A Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I, I54L, L76V, I84V L10F I13V, G16E, K20I, L33L_L, E35D, M36I, R57K, Q61R, L63T, H69K, L89I, T91TS  
>4153-30326| codons 1-99
PQITLWQRPFVTVKIEGQLIEALLDTGADDTVLEDINLPGRWKPKIIGGIGGFLKVKQYD
RITIEICGKKAIGTVVVGPTPVNVIGRNILSQIGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, K70R, M184MIV, T215F D67S, K219E Y181C, G190A   P4S, K11T, K20R, V21I, V35T, T39Q, T69N, L109I, K122E, D123N, I135T, K173S, Q174K, D177E, T200A, I202V, Q207A, R211K, D218E, V245Q, E248D, T286A, E291D, V292I, I293V, P294T, E312G, G335D, M357Q, R358K, G359S, T369TA, A371V, I375V, A376S, K390R N137H
>4153-30326| codons 1-400
PISSIETVPVTLKPGMDGPRIKQWPLTEEKIKALTEICQELEKEGKISKIGPENPYNTPV
FAIKKKSSNRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVIDVGDAYFSVPL
DENFRKYTAFTIPSTNHETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRSKNPEIVI
CQYVDDLYVASDLEIGQHRAKVEELRAHLLKWGFFTPEEKHQKEPPFLWMGYELHPDKWT
VQPIQLPDKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGAKALTDIVTLTEEAE
LELAENREILKGPVHGVYYDPSKDLIAEIQKQGQDQWTYQIYQEPFKNLKTGKYARQKSA
HTNDVKQLAEVVQKVSTESIVIWGKTPKFRLPIQKETWEA

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006