Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-4153 | 4153-30326 | Germany | 2003 | HIV1 | A | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54L, L76V, I84V | L10F | I13V, G16E, K20I, L33L_L, E35D, M36I, R57K, Q61R, L63T, H69K, L89I, T91TS |
| >4153-30326| codons 1-99 PQITLWQRPFVTVKIEGQLIEALLDTGADDTVLEDINLPGRWKPKIIGGIGGFLKVKQYD RITIEICGKKAIGTVVVGPTPVNVIGRNILSQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, K70R, M184MIV, T215F | D67S, K219E | Y181C, G190A | P4S, K11T, K20R, V21I, V35T, T39Q, T69N, L109I, K122E, D123N, I135T, K173S, Q174K, D177E, T200A, I202V, Q207A, R211K, D218E, V245Q, E248D, T286A, E291D, V292I, I293V, P294T, E312G, G335D, M357Q, R358K, G359S, T369TA, A371V, I375V, A376S, K390R | N137H |
| >4153-30326| codons 1-400 PISSIETVPVTLKPGMDGPRIKQWPLTEEKIKALTEICQELEKEGKISKIGPENPYNTPV FAIKKKSSNRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVIDVGDAYFSVPL DENFRKYTAFTIPSTNHETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRSKNPEIVI CQYVDDLYVASDLEIGQHRAKVEELRAHLLKWGFFTPEEKHQKEPPFLWMGYELHPDKWT VQPIQLPDKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGAKALTDIVTLTEEAE LELAENREILKGPVHGVYYDPSKDLIAEIQKQGQDQWTYQIYQEPFKNLKTGKYARQKSA HTNDVKQLAEVVQKVSTESIVIWGKTPKFRLPIQKETWEA |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |