<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-4152 4152-40205 Germany 2004 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA
2 NRTI+NNRTI+RTV+TPV 45

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
G48M, I54S, V82AT, I84V, L90M Q58QE L10I, K20R, E34R, E35D, M36I, N37S, R41K, R57RK, D60DE, I62V, L63P, A71V, V77I, I93L  
>4152-40205| codons 1-99
PQITLWQRPIVTIKIGGQLREALLDTGADDTVLRDISLPGKWKPKMIMGIGGFSKVKEYE
QVPIEICGHKVIGTVLIGPTPTNVIGRNLMTQLGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, L74V, L210W, T215Y K219N Y181YC   T39A, E40F, K43E, K64R, V118I, K122E, S162C, I195IT, G196E, T200TA, E203D, H208Y, R211K, D218DE, A272P, I293IV, I326V, I329V, Q334D, K350KR, M357V, R358K, E370Q, T386I  
>4152-40205| codons 1-400
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICAFLEEEGKISKIGPENPYNTPV
FAIRKKNSTKWRKVVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSIPL
DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQCSMTKILEPFRKQNPDIVI
CQYMDDLYVGSDLETEQHRAKIDELRQYLWKWGFYTPENKHQKEPPFLWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKALTEVVPLTEEAE
LELAENREILKEPVHGVYYDPSKDLVAEVQKQGDGQWTYQIYQEPFKNLRTGKYARVKGA
HTNDVKQLTQAVQKIATESIVIWGKIPKFKLPIQKETWEA

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006