<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-4150 4150-30407 Germany 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
D67N, M184V, T215F K219E K103N, Y181C   E6EK, K20R, V35M, T39AS, K122E, I135M, S163T, V179I, Q197E, I202V, R211K, W212WG, L228LF, V245Q, A272P, I293V, K311R, E312EG, Q334N, G335S, R358K, G359S, V365I, T369TA, A371V, I375T, T386I, K390R  
>4150-30407| codons 1-399
PISPIKTVPVKLKPGMDGPRVKQWPLTEEKIKALMEICSEMEKEGKISKIGPENPYNTPV
FAIKKKNSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL
DEDFRKYTAFTIPSMNNETPGIRYQYNVLPQGWKGSPAIFQSTMTKILEPFRKQNPDIII
CQYVDDLYVGSDLEIGEHRTKVEELRQHLLKGGFFTPDEKHQKEPPFFWMGYELHPDKWT
VQPIQLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKALTEVVPLTEEAE
LELAENREILRGPVHGVYYDPSKDLIAEIQKQGNSQWTYQIYQEPFKNLKTGKYARMKSA
HTNDIKQLAEVVQKTATESIVIWGKIPKFRLPIQKETWE

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46L, G48GV, I54LV, L76LV, V82A, I84IV L24I, L33F, F53FL L10I, I13V, N37E, K43KR, K55KR, D60DE, Q61QHKN, L63AEPQ, I64IV, A71V, I72V, V77I, I93L  
>4150-30407| codons 1-99
PQITLWQRPIVTVKIGGQLKEALIDTGADDTVFEEMELPGRWRPKLIVGIGGLVRVRQYE
NIQVEICGHKVVGTVVIGPTPANVIGRNLLTQLGCTLNF

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006