Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-4150 | 4150-30407 | Germany | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, G48GV, I54LV, L76LV, V82A, I84IV | L24I, L33F, F53FL | L10I, I13V, N37E, K43KR, K55KR, D60DE, Q61QHKN, L63AEPQ, I64IV, A71V, I72V, V77I, I93L |
| >4150-30407| codons 1-99 PQITLWQRPIVTVKIGGQLKEALIDTGADDTVFEEMELPGRWRPKLIVGIGGLVRVRQYE NIQVEICGHKVVGTVVIGPTPANVIGRNLLTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, M184V, T215F | K219E | K103N, Y181C | E6EK, K20R, V35M, T39AS, K122E, I135M, S163T, V179I, Q197E, I202V, R211K, W212WG, L228LF, V245Q, A272P, I293V, K311R, E312EG, Q334N, G335S, R358K, G359S, V365I, T369TA, A371V, I375T, T386I, K390R |
| >4150-30407| codons 1-399 PISPIKTVPVKLKPGMDGPRVKQWPLTEEKIKALMEICSEMEKEGKISKIGPENPYNTPV FAIKKKNSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL DEDFRKYTAFTIPSMNNETPGIRYQYNVLPQGWKGSPAIFQSTMTKILEPFRKQNPDIII CQYVDDLYVGSDLEIGEHRTKVEELRQHLLKGGFFTPDEKHQKEPPFFWMGYELHPDKWT VQPIQLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKALTEVVPLTEEAE LELAENREILRGPVHGVYYDPSKDLIAEIQKQGNSQWTYQIYQEPFKNLKTGKYARMKSA HTNDIKQLAEVVQKTATESIVIWGKIPKFRLPIQKETWE |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |