<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-4149 4149-30403 Germany 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
V32I, M46I, I47V, I54M, L90M L10FI, V11I, L33F, G73S E34Q, R41K, I62IV, L63P, A71V, V77I, I93L  
>4149-30403| codons 1-99
PQITLWQRPIITIKIGGQLKEALLDTGADDTIFQEMNLPGKWKPKIVGGIGGFMKVRQYD
QVPIEICGHKVISTVLIGPTPVNIIGRNLMTQLGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, L74I, M184MIV, L210W, T215Y V75T, K219N Y181C, Y188L F227FL K20R, V35M, K43E, E44A, R83K, W88WC, K102M, V106VI, V118I, K122E, D123E, D177E, I178M, V189I, G196E, E203K, Q207E, H208Y, R211K, A272P, T286A, E297K, K311KR, I329V, Q334L, G359S, A371V, K390KR K223KAET
>4149-30403| codons 1-399
PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALMEICTELEEAGKISKIGPENPYNTPV
FAIKKKNSTKWRKITDFRELNKKTQDFCEVQLGIPHPAGLKMKKSITVLDVGDAYFSIPL
DEEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPEMVI
CQYVDDLLIGSDLEIEQHRTKIKELREYLWKWGFYTPDNKHQTEPPLLWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGAKALTEVIPLTKEAE
LELAENREILREPVHGVYYDPSKDLIAEVQKQGLGQWTYQIYQEPFKNLKTGKYARMRSA
HTNDVKQLTEVVQKIATESIVIWGKTPKFRLPIQKETWE

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006