Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-4149 | 4149-30403 | Germany | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32I, M46I, I47V, I54M, L90M | L10FI, V11I, L33F, G73S | E34Q, R41K, I62IV, L63P, A71V, V77I, I93L |
| >4149-30403| codons 1-99 PQITLWQRPIITIKIGGQLKEALLDTGADDTIFQEMNLPGKWKPKIVGGIGGFMKVRQYD QVPIEICGHKVISTVLIGPTPVNIIGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L74I, V75T, M184MIV, L210W, T215Y | K219N | Y181C, Y188L | F227FL | K20R, V35M, K43E, E44A, R83K, W88WC, K102M, V106VI, V118I, K122E, D123E, D177E, I178M, V189I, G196E, E203K, Q207E, H208Y, R211K, A272P, T286A, E297K, K311KR, I329V, Q334L, G359S, A371V, K390KR | K223KAET |
| >4149-30403| codons 1-399 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALMEICTELEEAGKISKIGPENPYNTPV FAIKKKNSTKWRKITDFRELNKKTQDFCEVQLGIPHPAGLKMKKSITVLDVGDAYFSIPL DEEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPEMVI CQYVDDLLIGSDLEIEQHRTKIKELREYLWKWGFYTPDNKHQTEPPLLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGAKALTEVIPLTKEAE LELAENREILREPVHGVYYDPSKDLIAEVQKQGLGQWTYQIYQEPFKNLKTGKYARMRSA HTNDVKQLTEVVQKIATESIVIWGKTPKFRLPIQKETWE |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |