Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-4147 | 4147-30325 | Germany | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32I, M46I, I47V, I50V, I54L, L90M | L33I, K43T, L89V | T12S, I13V, K20T, E35D, M36I, N37DE, L63P, A71IV, V77L, P79S, V82I, I93L |
| >4147-30325| codons 1-99 PQITLWQRPLVSVKIGGQLTEALLDTGADDTIIEDIELPGRWTPKIVGGVGGFLKVRQYD QIPIEICGHKVIGTVLLGSTPINIIGRNVMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, T69S_XG, L74V, M184MI, T215HY | D67S | K103KN, Y181C, G190GA | K101H, V108I | E28K, K32E, V90I, K122E, D123E, I135T, A158S, K166R, V189I, G196E, T200A, I202V, E204K, A272P, K277R, E297K, M357T, A360T, K390R | N175E |
| >4147-30325| codons 1-399 PISPIETVPVKLKPGMDGPKVKQWPLTKEKIEALVEICTELEKEGKISKIGPENPYNTPV FAIKKKSSSKWRKVVDFRELNKRTQDFWEIQLGIPHPAGLHKNKSVTILDVGDAYFSVPL DEEFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPSIFQSSMTRILEPFRKQEPDIVI CQYIDDLYIASDLEIEQHRAKVEKLRQHLLRWGFYTPDKKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGTKALTEVIPLTKEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARTRGT HTNDVKQLTEAVQKIATESIVIWGKTPKFRLPIQKETWE |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |