<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-4145 4145-30530 Germany 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
V32I, M46I, I54M, I84V, L90M L33F, K43T, G73S, L89V L10V, I13V, G16A, K20L, F53Y, D60E, L63P, I66F, A71V, I72L, P79N  
>4145-30530| codons 1-99
PQITLWQRPVVTVKIAGQLLEALLDTGADDTIFEEMNLPGRWTPKIIGGIGGYMKVRQYE
QIPIEFCGHKVLSTVLVGNTPVNVIGRNVMTQIGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, M184V, L210W, T215Y   K103N   K20R, T39A, K43E, K49R, V118I, K122E, D123DN, I135T, T200A, K223Q, L228R, A272P, K277KR, I293V, T296S, D324E, G333E, Q334H, E370D, T377Q, K390R  
>4145-30530| codons 1-400
PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALVEICAELEEEGKISRIGPENPYNTPV
FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSIPL
DENFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI
YQYVDDLYVGSDLEIGQHRAKIEELRQHLWRWGFYTPDKKHQQEPPFRWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGTKALTEVVPLSEEAE
LELAENREILKEPVHGVYYDPSKELIAEIQKQEHGQWTYQIYQEPFKNLKTGKYARMRGA
HTNDVKQLTDAVQKIAQESIVIWGKTPKFRLPIQKETWEA

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006