Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-4144 | 4144-30826 | Germany | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, K70R, L74V, V75T, T215F | K219Q | K103N, Y181C | E6EK, K20R, K43Q, K64H, T69N, K122E, I135T, I142T, S162Y, Q207E, D218E, L228H, V245E, I293V, R356RK, G359S, T369A, A371V, T377M |
| >4144-30826| codons 1-399 PISPIKTVPVKLKPGMDGPRVKQWPLTEEKIKALVEICTELEQEGKISKIGPENPYNTPV FAIHKKNSNRWRKVTDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL DEDFRKYTAFTIPSTNNETPGTRYQYNVLPQGWKGSPAIFQYSMTKILEPFRKQNPDIVI CQYMDDLYVGSDLEIGQHRTKIEELREHLLRWGFFTPEQKHQKEPPFHWMGYELHPDKWT VQPIELPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGTKALTEVVPLTEEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYAKMRSA HTNDVKQLAEVVQKIAMESIVIWGKTPKFKLPIQKETWE |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46MI, I54V, V82A, L90M | L10F, L33LF | I13V, L19I, K20M, E35ED, M36I, R41K, I62V, L63P, I64IV, L89LM, Q92K, C95CF |
| >4144-30826| codons 1-99 PQITLWQRPFVTVKIGGQIMEALLDTGADDTVFEDINLPGKWKPKIIGGIGGFVKVRQYD QVPVEICGHKAIGTVLVGPTPANIIGRNMMTKIGFTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |