Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-4143 | 4143-30408 | Germany | 2003 | HIV1 | CRF01_AE | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| G48V, I54A, V82S | L10V, I15V, L19I, K20R, E35D, M36I, R41K, I62V, L63V, H69K, T74S, L89M, I93L |
| >4143-30408| codons 1-99 PQITLWQRPVVTIKVGGQIREALLDTGADDTVLEDINLPGKWKPKMIVGIGGFAKVRQYD QVVIEICGKKAIGSVLVGPTPSNIIGRNMLTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, K70R, V75M, T215F | K219Q | E6N, K11T, V35T, E36A, T39K, K43E, V60I, V90I, K122E, D123NS, I135V, I142V, S162H, K173S, D177E, V179I, I202V, Q207A, L228H, V245Q, E248D, D250DE, A272P, T286A, E291D, V292VI, I293V, P294T, E312D, G335D, M357K, G359S, K366R, T369V, E370D, A371V, I375V, A376V, T377M, T386A |
| >4143-30408| codons 1-399 PISPINTVPVTLKPGMDGPKVKQWPLTEEKIKALTAICKELEEEGKISKIGPENPYNTPI FAIKKKNSDRWRKLMDFRELNKRTQDFWEIQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DESFRKYTAFTIPSVNNETPGVRYQYNVLPQGWKGSPAIFQHSMTKILEPFRSQNPEIII YQYMDDLYVGSDLEIGQHRTKVEELRAHLLRWGFFTPDQKHQKEPPFHWMGYELHPDKWT VQPIQLPDKESWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGAKALTDIVTLTEEAE LELAENREILKDPVHGVYYDPSKDLIAEIQKQGQDQWTYQIYQEPFKNLKTGKYARKRSA HTNDVRQLVDVVQKVVMESIVIWGKAPKFKLPIQKETWE |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |