Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-4142 | 4142-30325 | Germany | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, T69D, L74I, L210W, T215Y | D67G, K219R | Y188L | V35I, K43E, E44A, R83K, K102M, V106I, V118I, K122E, T139A, I142V, D177G, I178M, T200A, E203D, Q207E, H208F, R211K, D218E, K223KQ, L228R, V245E, I293V, E297K, M357T, D364E, K390R |
| >4142-30325| codons 1-399 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALIEICTELEEAGKISKIGPENPYNTPV FAIKKKGSDKWRKIVDFRELNKKTQDFWEVQLGIPHPAGLKMKKSITVLDVGDAYFSIPL DEDFRKYTAFTIPSINNEAPGVRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPGMVI YQYMDDLLVGSDLEIGQHRAKIDELREFLWKWGFYTPERKHQQEPPFRWMGYELHPDKWT VQPIELPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGTKALTEVVPLTKEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARTRGA HTNEVKQLTEAVQKIATESIVIWGKTPKFRLPIQKETWE |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32I, M46L, I47V, I54V, V82A, L90M | L33F, F53L | L10V, I15IV, K20R, E35D, M36I, N37D, R41K, K55R, R57K, L63P, A71L, I93L |
| >4142-30325| codons 1-99 PQITLWQRPVVTIKVGGQLREALLDTGADDTIFEDIDLPGKWKPKLVGGIGGLVRVKQYD QIPIEICGHKLIGTVLVGPTPANIIGRNLMTQLGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |