<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-4142 4142-30325 Germany 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, T69D, L74I, L210W, T215Y D67G, K219R Y188L   V35I, K43E, E44A, R83K, K102M, V106I, V118I, K122E, T139A, I142V, D177G, I178M, T200A, E203D, Q207E, H208F, R211K, D218E, K223KQ, L228R, V245E, I293V, E297K, M357T, D364E, K390R  
>4142-30325| codons 1-399
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALIEICTELEEAGKISKIGPENPYNTPV
FAIKKKGSDKWRKIVDFRELNKKTQDFWEVQLGIPHPAGLKMKKSITVLDVGDAYFSIPL
DEDFRKYTAFTIPSINNEAPGVRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPGMVI
YQYMDDLLVGSDLEIGQHRAKIDELREFLWKWGFYTPERKHQQEPPFRWMGYELHPDKWT
VQPIELPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGTKALTEVVPLTKEAE
LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARTRGA
HTNEVKQLTEAVQKIATESIVIWGKTPKFRLPIQKETWE

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
V32I, M46L, I47V, I54V, V82A, L90M L33F, F53L L10V, I15IV, K20R, E35D, M36I, N37D, R41K, K55R, R57K, L63P, A71L, I93L  
>4142-30325| codons 1-99
PQITLWQRPVVTIKVGGQLREALLDTGADDTIFEDIDLPGKWKPKLVGGIGGLVRVKQYD
QIPIEICGHKLIGTVLVGPTPANIIGRNLMTQLGCTLNF

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006